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Management of Large Congenital Melanocytic Nevi: Outcomes Study of Serial Excision
Aladdin H. Hassanein, MD, MMSc1, Gary F. Rogers, MD, JD, MBA, MPH2, Arin K. Greene, MD, MMSc1.
1Harvard Medical School, Boston Children's Hospital, Boston, MA, USA, 2Children's National Medical Center, Washington, DC, USA.

BACKGROUND: Large congenital melanocytic nevi (LCMN) cause significant deformity and are at risk for malignant degeneration. Techniques used to remove these lesions include serial excision, skin grafting, or tissue expansion. Some authors prefer skin grafting or tissue expansion if several stages would be required to serially resect the LCMN. The purpose of this study was to determine the efficacy of serial excision for LCMN requiring 3 or more procedures.
METHODS: Medical records and clinical images of patients with LCMN treated between 2007 and 2013 were reviewed. Inclusion criteria were: (1) lesions that required at least 3 serial excisions to remove and (2) LCMN that could have been treated reasonably with skin grafting or tissue expansion. Patient age, gender, location of the lesion, size of the CMN, number of serial excisions, and complications were recorded.
RESULTS: The study included 21 patients (11 males, 10 females). Lesions were located on the lower extremity (38.1%), head/neck (33.3%), upper extremity (14.3%), or trunk (14.3%). Nevus size was 2.2% ± 1.2% total body surface area. The age during the first operation was 4.3 years (range 3 months to 15 years). The number of excisions was 3.5 ± 0.7, spaced 8.2 ± 4.3 months apart. Partial suture line dehiscence occurred after 2/72 (2.7%) operations and seroma resulted after 1/72 operations (1.4%); there were no infections.
CONCLUSIONS: LCMN amenable to serial excision can be removed effectively and safely using this technique. Children are left with a favorable linear scar, do not have donor or recipient site morbidity from skin grafting, and are not subjected to potential tissue expander complications and injections required for expansion.


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